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Effexor (Venlafaxine) - Purchase Online
Brand Names: Effexor, Effexor XR
Generic Name: Venlafaxine
Systematic (IUPAC) name: 1-[2-dimethylamino-1-(4-methoxyphenyl)- ethyl]cyclohexan-1-ol or (?)-1-[a [a-(dimethylamino)methyl]p-methoxybenzyl] cyclohexanol hydrochloride
Chemical Formula: C17H27NO2
Effexor is an antidepressant in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Effexor affects chemicals in the brain that may become unbalanced and cause depression.
Effexor's active agent - Venlafaxine - is structurally and pharmacologically related to the analgesic Tramadol, but not to any of the conventional antidepressant drugs, including tricyclic antidepressants, Selective serotonin reuptake inhibitors (SSRI), Monoamine oxidase inhibitors (MAOI), or reversible inhibitors of monoamine oxidase A.
Venlafaxine is not a controlled substance.
Supplied as:
Inactive ingredients in the tablets/capsules consist of cellulose, ethylcellulose, gelatin, hypromellose, iron oxide, and titanium dioxide.
In Australia and New Zealand, venlafaxine XR tablets are sold under the name "Efexor-XR" (note the spelling with one 'f', rather than "Effexor-XR").
The extended release (XR) version controls the release of the drug into the gastrointestinal tract over a longer period than normal venlafaxine. This results in a lower peak plasma concentration and a lower incidence of patients suffering from nausea as a side effect.
Effexor is used primarily for the treatment of depression, generalized anxiety disorder, social anxiety disorder, and panic disorder in adults. Venlafaxine is perhaps one of the most likely of all modern antidepressants to trigger manic and hypomanic states. As a result, it is not recommended as a first line treatment of depression. However, it is often effective for depression not responding to SSRIs.
Studies have shown Effexor (venlafaxine)'s effectiveness for the treatment of diabetic neuropathy (in a similar manner to duloxetine) and migraine prophylaxis. It has also been found to reduce the severity of 'hot-flashes' in menopausal women.
Because of its tendency to increase blood pressure and its ability to re-regulate the autonomic nervous system, Effexor (venlafaxine) is often used to treat orthostatic intolerance and postural orthostatic tachycardia syndrome.
Effexor's toxicity appears to be higher than other SSRIs, with a fatal toxic dose closer to that of the tricyclic antidepressants than the SSRIs. Doses of 900 mg or more are likely to cause moderate toxicity. Deaths have been reported following very large doses.
Do not take this medication if you are allergic to Effexor, or if you are also using a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).
Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, medicine for seizures, other medication for depression or anxiety). They can add to sleepiness caused by Effexor.
Avoid drinking alcohol, which can increase some of the side effects of Effexor. Using too much of this medicine in addition to drinking alcohol can cause death.
Effexor can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Before taking Effexor, tell your doctor if you are allergic to any medications, or if you have:
If you have any of the conditions listed above, you may not be able to take Effexor, or you may need a dosage adjustment or special monitoring during treatment.
Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.
Effexor may be harmful to an unborn baby, and may cause problems in a newborn baby if the mother takes the medication late in pregnancy (during the third trimester). Tell your doctor if you are pregnant or plan to become pregnant during treatment. Effexor can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.
Effexor XR should be administered in a single dose with food either in the morning or in the evening at approximately the same time each day.
For most patients, the recommended starting dose for Effexor is 75 mg/day, administered in a single dose. For some patients, it may be desirable to start at 37.5 mg/day for 4 to 7 days, to allow new patients to adjust to the medication before increasing to 75 mg/day. While the relationship between dose and antidepressant response for Effexor has not been adequately explored, patients not responding to the initial 75 mg/day dose may benefit from dose increases to a maximum of approximately 225 mg/day. Dose increases should be in increments of up to 75 mg/day, as needed, and should be made at intervals of not less than 4 days.
It may take 4 weeks or more for your symptoms to improve. For best results, keep using the medication as directed.
Effexor should be taken with food. Swallow the extend release capsule whole, without crushing or chewing.
Do not take extra medicine to make up the missed dose.
Symptoms of a Effexor overdose may include dizziness, sleepiness, nausea, and numbness or tingling in your hands or feet.
Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Contact your doctor promptly if you have any of the following side effects, especially if they are new symptoms or if they get worse: mood changes, anxiety, panic attacks, trouble sleeping, irritability, agitation, aggressiveness, severe restlessness, mania (mental and/or physical hyperactivity), thoughts of suicide or hurting yourself.
Call your doctor at once if you have any of these serious side effects:
Other less serious side effects are more likely to occur, such as:
Before taking Effexor, tell your doctor if you are using any of the following medicines:
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